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Intelligent Matter Lab

What if active materials can learn? Living systems assemble, adapt, and generate function through the interactions of many parts. We ask how those principles can become a foundation for a new kind of physical system.

Our long-term vision is intelligent matter: collections of simple physical units whose local rules enable the whole to sense, reorganize, and act. We approach that vision through experiments in living matter, programmable robotic systems, and learning.

Physics of Emergence

We discover how local, nonreciprocal interactions generate new collective dynamics and states of matter.

Learning & Memory

We investigate how local rules can be learned and how physical interactions and material states can encode memory.

Information organization

We seek to understand how distributed sensing, learning, and information exchange can produce adaptable collective functions.

​​The possibility is a new approach to embodied intelligence: complex collective functions arising from learned interactions among many simple physical units. If these principles generalize, they could provide a foundation for adaptable robotic swarms, reconfigurable machines, and eventually intelligent materials.

01 / ROBOTIC MATTER

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Physics of Emergence

How do simple local interactions give rise to complex collective behaviors? We investigate the fundamental physical principles governing self-organization, collective dynamics, and emergent properties in active matter.

[ Learn more | preprint ]

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Learning & Memory

Can physical matter learn, remember, and adapt through its own interactions? We combine statistical physics and machine learning to uncover how collective systems can acquire new functions and encode memories in their physical dynamics.

[ Learn more ]

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Information-driven organization

Can interacting physical systems become a substrate for collective intelligence? We explore how information exchange, distributed decision-making, and embodied AI can transform robotic swarms into intelligent, adaptive collectives.

[ Learn more ]

02 / LIVING MATTER

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Morphological Manifold

How can biological shape reveal cell identity, developmental states, and trajectories? We combine machine learning and symmetry analysis to uncover how cell and tissue morphology encode biological states and evolve during development.

[ Learn more | Review ]

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Nonreciprocal living & active matter

Living systems are full of interactions that break action-reaction symmetry, from ciliary flows to chiral tissues. We study how nonreciprocal interactions generate collective motion, odd mechanical response and emergent organization in living matter.

[ Learn more | nature ]

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Chiral Morphogenesis 

How does chirality emerge and break left-right symmetry during development? We study sea star embryos to uncover the physical mechanisms driving chiral morphogenesis.

[ Learn more | PRX Life ]

Principal Investigator​

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Tzer Han Tan is an Assistant Professor of Physics at UC San Diego. He leads a research lab developing living and synthetic active matter systems to better understand physical principles that underlie complexity in collective behavior. Before joining UC San Diego, he was a ELBE Postdoctoral Fellow at the Max Planck Institute for Physics of Complex Systems. Tzer Han received his Ph.D. in Physics at MIT and his B.S. in Applied and Engineering Physics at Cornell University. Tzer Han's awards include the William A. Lee Chancellor's Endowed Junior Faculty Fellowship, Hellman Fellowship and the DOE Early Career Award.​​​

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News

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Oct 2026: Tzer Han has been awarded a DOE Early Career Award to study physical learning in nonreciprocal active matter. Very honored!

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Sep 2026: Andrew Truttman has been selected as a NIH T32 student fellow to study mechanisms of mitotic waves. Congrats Andrew!

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May 2026: Tzer Han has received a NIH MIRA (R35) Award to study morphological landscape to define cell states and cell types using representation learning.

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Mar 2026: Ouyang Xuan has been selected as a Keck Student Fellow to study morphological landscape of tissues. Congrats Xuan!

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Feb 2026: Tzer Han has received a DARPA Defense Science Office (DSO) Pitch Day award! With co-PI Prof. Gravish and Prof. Boechler, they will develop robotic swarms as programmable states of matter.

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Aug 2025: Shiqi Liu joins the lab, working on physical learning in nonreciprocal robotic matter. Welcome Shiqi!​

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July 2025: Tzer Han has been selected as UCSD Hellman Fellows. Congratulations!​

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team members

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Fan Bo

Postdoctoral Fellow

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Shiqi Liu

Postdoctoral Fellow

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Wyatt Joyce

PhD student

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Gregor Leech

PhD Student

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Ouyang Xuan

PhD student

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Andrew Truttman

PhD student

Undergraduate Students

  • Zenghong He (Electrical Engineering, Class of 2026)

  • Hrithik Yash (Mechanical Engineering, Class of 2027)

  • Eyad Alqatari (Physics, Class of 2028)

  • Feiyi Ruan (Computer Science)

  • Haruhiko Akimoto (Physics, Class of 2027)

  • Jeremy Lin (Electrical Engineering, Class of 2027)​​

  • Logan Wong (Electrical Engineering, Class of 2027)

Alumni

  • Yutao Deng (currently Masters at CMU)

  • Zeyu Qi (soon Masters at Columbia U)

our team is recruiting

We are looking for motivated and creative undergraduate/PhD/postdocs to join our team!

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In particular, the active research directions in the lab are:

  1. Chiral active matter, with a focus on phase transitions, the role of disorder and collective dynamics using marine invertebrate embryos (e.g. P. miniata, Platynereis) as model

  2. Nonreciprocal robotic active matter, with a focus on designing odd elasticity, nonreciprocal phase transiton and active learning using our newly developed p-atic robotic active matter.

  3. Chiral morphogenesis, with a focus on chiral symmetry breaking in marine embryos, morphological landscape of organoids, optogenetics, tissue mechanics and mechanochemical coupling 

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Our lab is primarily an experimental soft matter/biophysics lab with plenty of opportunities to collaborate with theory groups. We aim to combine experiments with creative data analysis to understand how symmetry, order and dynamics emerge in living matter. ​

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Postdocs. Please email Tzer Han directly with CV and a short statement of interest. We welcome applicants from diverse and international background.

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PhD and undergraduate students. Students already at UCSD can contact Tzer Han directly. Otherwise, you can apply to the Physics PhD program here. Deadline Dec 18, 2026.

publication

Three phases of odd robotic active matter

Bo F, Liu S, He Z, Joyce W, Leech G, Tran K, Ramirez K, Boechler N, Gravish N, Zhao H, Tan TH^
Preprint available (2026). [ arXiv ]

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Light-induced cortical excitability reveals programmable shape dynamics in starfish oocytes.

Liu J*, Burkart T*, Ziepke A, Reinhard J, Chao YC, Tan TH, Swartz SZ, Frey E, Fakhri N.

Nature Physics (2025).

[ MIT News | LMU News ]

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Quantifying irreversibility of ecological systems.

Li J, Munch S, Tan TH, Song CL.

Preprint on bioRxiv (2024). Submitted.

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Emergent chirality in active solid rotation of pancreas spheres.

Tan TH*, Amiri A*, Barandiaran IS*, Staddon M, Hermann A, Tomas S, Duclut C, Papovic M, Julicher F, Grapin-Botton A.

PRX Life (2024). 

[ Research Highlight in Physics News ]

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Odd dynamics of living chiral crystals.

Tan TH*, Mietke A*, Li J, Chen Y, Higinbotham H, Gokhale S, Foster PJ, Dunkel J, Fakhri N.

Nature (2022), 607(7918), 287-293

[ News and Views | Nature Video | MIT news | sciencealert.com | New Scientist | Discover magazine ]

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Mapping and exploring the organoid state space using synthetic biology.

Tan TH*, Liu J*, Grapin-Botton A.

Seminars in Cell and Developmental Biology (2022). Academic Press.

 

Polarized Dishevelled dissolution and condensation drives embryonic axis specification in oocytes.

Swartz SZ, Tan TH, Perillo M, Fakhri N, Wessel GM, Cheeseman IM, Wikramanayake I.

Current Biology (2021). 31(24), 5633-5641.

 

Scale-dependent irreversibility in living matter.

Tan TH*, Watson GA*, Chao YC*, Gingrich TR, Horowitz JM, and Fakhri N.

Preprint on arXiv (2021). Submitted.

 

A hierarchy of protein patterns robustly decodes cell shape information.

Wigbers M*, Tan TH*, Brauns F, Jinghui L, Swartz Z, Frey E, Fakhri N.

Nature Physics (2021).

[ LMU news | phys.org ]

 

Topological turbulence in the membrane of a living cell.

Tan TH*, Liu J*, Miller PW*, Tekant M, Dunkel J, and Fakhri N.

Nature Physics (2020).

[ PDF | Nature Physics cover art | MIT news | phys.org | physicsworld.com | Research highlight in Nature ]

 

Self-organized stress patterns drive state transitions in actin cortices.

Tan TH*, Malik-Garbi M*, Abu-Shah E*, Li J, Sharma A, MacKintosh FC, Keren K, Schmidt CF and Fakhri N.

Science Advances (2018). 4(6), p.eaar2847.

[ F1000 article recommendation ]

 

Super-resolution imaging of fluorescently labeled, endogenous RNA Polymerase II in living cells with CRISPR/Cas9-mediated gene editing.

Cho WK, Jayanth N, Mullen S, Tan TH, Jung YJ and Cissé II.

Scientific reports (2016). 6, p.35949.

 

How grow-and-switch gravitropism generates root coiling and root waving growth responses in Medicago truncatula.

Tan TH, Silverberg JL, Floss DS, Harrison MJ, Henley CL and Cohen I,

Proceedings of the National Academy of Sciences (2015). 112(42), pp.12938-12943.

[ Research highlight in Nature Physics | Cornell Chronicle ]

 

(*denotes co-first authors)

Google scholar profile here.

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