[ living matter lab ]
explore our on-going projects here.
symmetry and order in living matter
Living matter at all scales has a remarkable capacity to grow, organize, heal and move. This capacity stems from its ability to convert energy at the molecular scale to generate macroscopic organized motion and emergent structures. The lab's overarching vision is to understand how nonequilibrium forces lead to spatiotemporal organization in living matter, and in turn, how biological regulation harness this self-organizing capacity to make functional forms.
Our lab is curiosity-driven, and we are interested in deciphering how order, symmetries and dynamics emerge in living matter. To do so, we draw inspiration from physics ideas in active matter, nonlinear dynamics and out-of-equilibrium statistical mechanics. By using a variety of model systems (including marine invertebrate embryos and mammalian organoids), the lab combines quantitative imaging, creative data analysis and collaboration with theorists to study the physical basis of biological organization.
our team is recruiting
We are looking for motivated and creative undergraduate/PhD/postdocs to join our team!
In particular, the two active research directions in the lab are:
Chiral active matter, with a focus on phase transitions, the role of disorder and collective dynamics using marine invertebrate embryos (e.g. P. miniata, Platynereis) as model
Organoid morphogenesis, with a focus on morphological landscape, optogenetics, tissue mechanics and mechanochemical coupling
Our lab is primarily an experimental/imaging lab with plenty of opportunities to collaborate with theory groups. We aim to combine experiments with creative data analysis to understand how symmetry, order and dynamics emerge in living matter.
Postdocs. Please email Tzer Han directly with CV and a short statement of interest. We welcome applicants from diverse and international background.
Tan TH*, Amiri A*, Barandiaran IS*, Staddon M, Hermann A, Tomas S, Duclut C, Papovic M, Julicher F, Grapin-Botton A.
Preprint on bioRxiv (2022). Submitted.
Tan TH*, Mietke A*, Li J, Chen Y, Higinbotham H, Gokhale S, Foster PJ, Dunkel J, Fakhri N.
Nature (2022), 607(7918), 287-293
Tan TH*, Liu J*, Grapin-Botton A.
Seminars in Cell and Developmental Biology (2022). Academic Press.
Swartz SZ, Tan TH, Perillo M, Fakhri N, Wessel GM, Cheeseman IM, Wikramanayake I.
Current Biology (2021). 31(24), 5633-5641.
Tan TH*, Watson GA*, Chao YC*, Gingrich TR, Horowitz JM, and Fakhri N.
Preprint on arXiv (2021). Submitted.
Wigbers M*, Tan TH*, Brauns F, Jinghui L, Swartz Z, Frey E, Fakhri N.
Nature Physics (2021).
Tan TH*, Liu J*, Miller PW*, Tekant M, Dunkel J, and Fakhri N.
Nature Physics (2020).
Tan TH*, Malik-Garbi M*, Abu-Shah E*, Li J, Sharma A, MacKintosh FC, Keren K, Schmidt CF and Fakhri N.
Science Advances (2018). 4(6), p.eaar2847.
[ F1000 article recommendation ]
Cho WK, Jayanth N, Mullen S, Tan TH, Jung YJ and Cissé II.
Scientific reports (2016). 6, p.35949.
Tan TH, Silverberg JL, Floss DS, Harrison MJ, Henley CL and Cohen I,
Proceedings of the National Academy of Sciences (2015). 112(42), pp.12938-12943.
(*denotes co-first authors)
Google scholar profile here.